Routing at Large Scale: Advances and Challenges for Complex Networks

International audienceA wide range of social, technological and communication systems can be described as complex networks. Scale-free networks are one of the well-known classes of complex networks in which nodes degree follow a power-law distribution. The design of scalable, adaptive and resilient routing schemes in such networks is very challenging. In this article we present an overview of required routing functionality, categorize the potential design dimensions of routing protocols among existing routing schemes and analyze experimental results and analytical studies performed so far to identify the main trends/trade-offs and draw main conclusions. Besides traditional schemes such as hierarchical/shortest-path path-vector routing, the article pays attention to advances in compact routing and geometric routing since they are known to significantly improve the scalability in terms of memory space. The identified trade-offs and the outcomes of this overview enable more careful conclusions regarding the (in-)suitability of different routing schemes to large-scale complex networks and provide a guideline for future routing research

Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity

As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed prepubertal (63 days-old) Duroc breed females (n=20) either with a standard growth diet (3800 KCal/day) or one with a high-calorie content (5200 KCal/day) during 70 days. Computerized tomography, mass-spectrometry based metabolomics, and lipidomics, as well as peripheral blood mononuclear cell transcriptomics, were applied to define traits linked to high-calorie intake. Samples from a human cohort confirmed potential lipidomic markers. Compared to those fed a standard growth diet, pigs fed a high-calorie diet showed an increased weight gain (13%), much higher adiposity (53%), hypertriacylglyceridemia and hypercholesterolemia, in parallel to insulin resistance. This diet induced marked changes in the circulating lipidome, particularly in phosphatidylethanolamine-type molecules. Also, circulating specific diacylglycerol and monoacylglycerol contents correlated with visceral fat and intrahepatic triacylglycerol concentrations. Specific lipids associated with obesity in swine (mainly belonging to glycerophospholipid, triacylglyceride, and sterol classes) were also linked with obesity-traits in the human cohort, reinforcing the usefulness of the chosen approach. Interestingly, no overt inflammation in plasma or adipose tissue was evident in this model. The presented model is useful as a preclinical surrogate of prepubertal obesity in order to ascertain the pathophysiology interactions between energy intake and obesity development.info:eu-repo/semantics/acceptedVersio